Molecular Basis of Human Sperm Capacitation
نویسندگان
چکیده
منابع مشابه
The molecular basis of sperm capacitation.
Testicular sperm that have undergone spermatogeneis and spermiogenesis appear mature from a morphological standpoint but have acquired neither progressive motility nor the ability to fertilize a metaphase Il-arrested egg. In many species, progressive motility and fertilization competence are acquired during epididyma! transit, but complete fertilization capacity in vivo is only gained upon resi...
متن کاملUnderstanding the molecular basis of sperm capacitation through kinase design.
T hirty years ago, on July 25, Steptoe and Edwards reported the birth of Louise Joy Brown, the first successful ‘‘Test-Tube’’ baby (1). This achievement followed a lack of success of in vitro fertilization experiments for almost 80 years since the first attempts in 1878. These early failures were due mainly to a lack of comprehension of sperm physiology. In the early 1950s, Chang (2) and Austin...
متن کاملBiological basis for human capacitation.
More than 50 years ago Austin and Chang defined mammalian sperm capacitation as a period of time that sperm must reside in the female reproductive tract before they acquire the ability to fertilize oocytes. Since then numerous investigations have attempted to more clearly define the molecules and processes that are a part of capacitation. The data that have provided a more clear definition of c...
متن کاملEffect of Astaxanthin on Human Sperm Capacitation
In order to be able to fertilize oocytes, human sperm must undergo a series of morphological and structural alterations, known as capacitation. It has been shown that the production of endogenous sperm reactive oxygen species (ROS) plays a key role in causing cells to undergo a massive acrosome reaction (AR). Astaxanthin (Asta), a photo-protective red pigment belonging to the carotenoid family,...
متن کاملBiological basis for human capacitation
More than 50 years ago Austin and Chang defined mammalian sperm capacitation as a period of time that sperm must reside in the female reproductive tract before they acquire the ability to fertilize oocytes. Since then numerous investigations have attempted to more clearly define the molecules and processes that are a part of capacitation. The data that have provided a more clear definition of c...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2018
ISSN: 2296-634X
DOI: 10.3389/fcell.2018.00072